By Janine Cossy,Gerard Cahiez,Catherine S.J. Cazin,Fabienne Fache,Bruno Figadere,Corinne Gosmini,Julien Legros,Alban Moyeux,David J. Nelson,Steve P. Nolan,Armelle Ouali,Beatrice Pelotier,Olivier Piva,Alice Rerat,Marc Taillefer
In 1912, the Chemistry Nobel Prize was once offered for the invention of the so-called Grignard reagents. these days, many transition steel versions are constructed to switch reactivity and selectivity of the C–C bond formation reaction.
The Grignard response is likely one of the primary organometallic reactions, usually utilized in alcohol syntheses. With transition metals like iron, cobalt and nickel or with noble metals like copper, silver and palladium, glossy Grignard reagents may be designed in reactivity, selectivity and useful workforce tolerance. This publication, written through foreign experts, provides an summary on well timed Grignard chemistry related to transition metals.
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